Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus
aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized
and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial
growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among
those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant
hospital clinical strain of S. aureus.
Keywords: Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.
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