Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity
Luciana Dalla-Vechia, Cíntia Janine Kiekow, Ivana Correa Ramos Leal, Katia Regina Netto Dos Santos, Simone Cristina Baggio Gnoatto, Hugo Verli, Rodrigo Octavio Mendonça Alves de Souza and Grace Gosmann
Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones were synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 μg/ml to a multidrug- resistant hospital clinical strain of S. aureus.
Antimicrobial, Aldol condensation, Chalcone, Phenolic compound
Faculdade de Farmácia Universidade Federal do Rio Grande do Sul UFRGS Av. Ipiranga 2752 Porto Alegre 90610-000 RS Brazil.