Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity

Author(s): Grace Gosmann, Rodrigo Octavio Mendonca Alves de Souza, Hugo Verli, Simone Cristina Baggio Gnoatto, Katia Regina Netto Dos Santos, Ivana Correa Ramos Leal, Cíntia Janine Kiekow, Luciana Dalla-Vechia.


Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant hospital clinical strain of S. aureus.

Keywords: Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.

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Article Details

Year: 2014
Page: [525 - 530]
Pages: 6
DOI: 10.2174/1570180810666131125221032
Price: $58