Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity

Author(s): Luciana Dalla-Vechia, Cíntia Janine Kiekow, Ivana Correa Ramos Leal, Katia Regina Netto Dos Santos, Simone Cristina Baggio Gnoatto, Hugo Verli, Rodrigo Octavio Mendonca Alves de Souza and Grace Gosmann

Affiliation: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, UFRGS, Av. Ipiranga, 2752, Porto Alegre, 90610-000, RS, Brazil.

Keywords: Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.

Abstract:

Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant hospital clinical strain of S. aureus.

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Article Details

VOLUME: 11
ISSUE: 5
Page: [525 - 530]
Pages: 6
DOI: 10.2174/1570180810666131125221032