Solid lipid nanoparticles (SLN) are very potential formulations for topical delivery of anti-inflammatory and
anti-arthritic drugs. The solid state of the lipid particles enable efficient drug encapsulation and controlled drug release. In
the present study, the evaluation of different formulation parameters based on variation of concentration of lipid and cosurfactant
was studied. The SLN gel formulations of the dispersions were compared to the SLN dispersions and with the
marketed gel of aceclofenac. The SLNs were prepared by high speed homogenization and ultra-sonication method with
fixed amount of aceclofenac (10%) and pluronic F68 (1.5%). The particle size, zeta potential and span of developed formulations
was found to be within the range of 123 nm to 323 nm, -12.4 to -18.5 and 0.42 to 0.86 respectively as the lipid
concentration was increased from 7.5% to 40%. The highest entrapment efficiency was found to be 75% with the formulation
having lipid concentration of 30% and 0.85% of phospholipon 90G. Permeation rate and controlled release property
of xanthan gum loaded SLN gel formulations and SLN dispersion was studied through excised pig skin for 24hr. The drug
release of SLN gel formulations was better controlled as compare to SLN dispersions. In vivo anti-inflammatory study
showed that action of aceclofenac was enhanced for SLN dispersion and gel formulations. The results indicated the superiority
of SLN based formulations for topical delivery of aceclofenac.
Keywords: Aceclofenac, Solid lipid nanoparticles (SLN), Xanthan gum.
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