Current Drug Discovery Technologies

  • Vladimir P. Torchilin  
    Department of Pharmaceutical Science Center
    for Pharmaceutical Biotechnology and Nanomedicine
    Northeastern University
    Boston, MA 02115
    USA

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The Importance of Epitope Binning for Biological Drug Discovery

Author(s): Benjamin D. Brooks

Affiliation: Wasatch Microfluidics, LLC, 825 North 300 West, Suite C325, Salt Lake City, UT 84103, USA.

Keywords: Antibody binning, antibody mapping, biotherapeutics drug discovery, drug discovery screening tools, epitope binning, epitope characterization, epitopes, R&D productivity.

Abstract:

The pharmaceutical industry is experiencing comeback sales growth due in large part to the industry’s R&D efforts that center on biologics drug development. To facilitate that effort, tools are being developed for more effective biologic drug development. At the forefront of this effort is epitope characterization, in particular epitope binning, primarily due to the role an epitope plays in drug function. Here we detail the financial advantages of epitope binning including (1) increased R&D productivity due to increased work in process, (2) reduced number of “dead-end”candidates, and (3) increasedability to reengineer antibodies based on the epitope. With the arrival of high throughput biosensors, this manuscript serves as a call to push epitope binning earlier in the biological drug discovery process.

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Article Details

VOLUME: 11
ISSUE: 2
Page: [109 - 112]
Pages: 4
DOI: 10.2174/1570163810666131124233827