The Importance of Epitope Binning for Biological Drug Discovery
Benjamin D. Brooks
Affiliation: Wasatch Microfluidics, LLC, 825 North 300 West, Suite C325, Salt Lake City, UT 84103, USA.
Keywords: Antibody binning, antibody mapping, biotherapeutics drug discovery, drug discovery screening tools, epitope binning,
epitope characterization, epitopes, R&D productivity.
The pharmaceutical industry is experiencing comeback sales growth due in large part to the industry’s R&D efforts
that center on biologics drug development. To facilitate that effort, tools are being developed for more effective biologic
drug development. At the forefront of this effort is epitope characterization, in particular epitope binning, primarily
due to the role an epitope plays in drug function. Here we detail the financial advantages of epitope binning including (1)
increased R&D productivity due to increased work in process, (2) reduced number of “dead-end”candidates, and (3) increasedability
to reengineer antibodies based on the epitope. With the arrival of high throughput biosensors, this manuscript
serves as a call to push epitope binning earlier in the biological drug discovery process.
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