Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives

Author(s): Chunlei Tang, Guolong Gu, Baowei Yang, Xuekun Wang, Hai Qian, Wenlong Huang, Xiaoyun Zhu, Jing Li.

Journal Name: Letters in Drug Design & Discovery

Volume 11 , Issue 5 , 2014

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In this study, combination-principle was reported to improve the hepatoprotective activity of andrographolide. Ten andrographolide derivatives were synthesized and evaluated for in vivo hepatoprotective activity in CCl4-induced liver injury mice. The pharmacological results revealed that 6 derivatives exhibited significant hepatoprotective activity. The most promising compound 6b significantly improved liver enzymes (ALT and AST) activity as compared with andrographolide, with high potency to be a new lead.

Keywords: Andrographolide, Combination-principle, Derivatives, Hepatoprotective, Natural products, Synthesis.

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Article Details

Year: 2014
Page: [677 - 685]
Pages: 9
DOI: 10.2174/1570180810666131123002409
Price: $58

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