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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
Epub Full Text Article
DOI: 10.2174/1570180810666131123002409      Price:  $95

Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives

Author(s): Chunlei Tang, Guolong Gu, Baowei Yang, Xuekun Wang, Hai Qian, Wenlong Huang, Xiaoyun Zhu and Jing Li
In this study, combination-principle was reported to improve the hepatoprotective activity of andrographolide. Ten andrographolide derivatives were synthesized and evaluated for in vivo hepatoprotective activity in CCl4-induced liver injury mice. The pharmacological results revealed that 6 derivatives exhibited significant hepatoprotective activity. The most promising compound 6b significantly improved liver enzymes (ALT and AST) activity as compared with andrographolide, with high potency to be a new lead.
Andrographolide, Combination-principle, Derivatives, Hepatoprotective, Natural products, Synthesis
Centre of Drug Discovery China Pharmaceutical University 24 Tongjiaxiang Nanjing, Jiangsu 210009 China.