Approach of novel drug delivery system (NDDS) overcomes the limitations of conventional dosage forms.
However, this concept is still not practiced to a large extent in delivery of herbal drugs in Ayurveda. Thus, the potential of
herbal drugs has not been explored to its fullest. Hence, there is a growing need to amalgamate the concept of NDDS in
delivery of herbal constituents. The present investigation is designed to deliver and retain two herbal constituents in stomach
for better action against Helicobacter pylori induced gastric ulcers. The objective was to develop a bilayer floating
tablet of ellagic acid and Aloe vera gel powder through rational combination of excipients to give the lowest possible lag
time with maximum drug release in the period of 4 h. Formulation F9 containing 100 mg of HPMC K15M, 27 mg of
crospovidone, 80 mg of mannitol and effervescent agents in the ratio 1:2 gave 92% drug release and desired floating
properties. In vivo studies showed that combination of ellagic acid and Aloe vera gave 75 % ulcer inhibition in comparison
to 57% ulcer inhibition in the group which was administered with ellagic acid alone. This suggests the use of bilayer
floating tablet in gastric ulcer treatment.
Keywords: Aloe vera, Ellagic acid, floating, gastric ulcer, optimization.
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