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Endocrine‚ Metabolic & Immune Disorders-Drug Targets
(Formerly Current Drug Targets - Immune‚ Endocrine & Metabolic Disorders)
ISSN (Print): 1871-5303
ISSN (Online): 2212-3873
VOLUME: 13
ISSUE: 4
DOI: 10.2174/1871530313666131122151325      Price:  $58









Specific Nutritional Supplement (Supportan®) in the Supportive Care of the Radio-Chemotherapy Treatment of Head and Neck Cancers: Biochemical Parameters. Preliminary Study

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Author(s): Octavio Casbarien, Pablo Cresta, Carolina Silva, Maria S. Feliu, Alejandra Badia, Norberto L. Delgado, Alfredo Navigante and Nora Slobodianik
Pages 348-350 (3)
Abstract:
Background: This is a preliminary study of a specific nutritional supplement –Supportan® - for the clinical support of patients with locally advanced head and neck (H&N) cancers who underwent treatment with concurrent radiochemotherapy (RT-CHT).

Material and Methods: Seven patients received nutritional supplement (Supportan®) plus habitual diet during a median time of treatment with RT on 7.8 weeks plus concurrent weekly CHT(S). Specific serum protein fractions as a potential useful tool to evaluate the nutritional status were determined. The main objective was to assess the compliance with the above-mentioned treatment.

Results: Patients completed the nutritional support, 5 / 7 patients via oral route and 2/7 patients through nasogastric tube. All studied patients, that completed treatment, had not severe mucositis –ulcera, hemrraghe and/ or infection. None of them had another severe toxicity by treatment nor had impairment of Pefomance Status. No differences in all specific sera proteins were observed between S and To.

Conclusion: In this preliminary study of few patients, we have observed a potential usefulness of Supportan® in the compliance of concurrent RT-CHT in patients with H&N cancers; moreover, its administration was useful to maintain the initial biochemical nutritional profile.

Keywords:
Biochemical parameters, neck and Head cancer, nutritional status, nutritional supplement, radio-chemotherapy.
Affiliation:
Department of Nutrition, School of Pharmacy and Biochemistry, UBA, Junin 956- 2nd Floor, 1113 Buenos Aires, Argentina.