Current Chromatography

Pavel N. Nesterenko
Australian Centre for Research on Separation Science (ACROSS)
School of Chemistry, University of Tasmania
Private Bag 75
Hobart, TAS 7001


Selected Problems on Ion Chromatography Determinations of Trace Elements in Clinical Samples

Author(s): Anna Blazewicz

Affiliation: Department of Analytical Chemistry, Medical University of Lublin, 4A Chodzki Street, 20-093 Lublin, Poland


The aim of this article is to introduce readers and clarify important issues related to the analysis of trace elements in clinical samples (biological fluids, tissues) using ion chromatography (IC). IC is a convenient analytical method for the analysis of ions in samples also with a complex matrix. However, despite the advances in technology and methodology, it is rather overlooked in the routine analysis of clinical samples. The problems faced by the analyst before and during the analysis of clinical samples and their influence on the interpretation of analytical data are discussed in the following review. Examples of speciation analyses involving IC are also presented. Topics are limited to selected trace elements and all applications described here are taken from published literature.

Keywords: Biofluids, blood, certified reference materials, clinical samples, collection, digestion, dilution, ion chromatography, preservation, serum, storage, toxicity, trace elements, urine, validation.

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Article Details

Page: [2 - 14]
Pages: 13
DOI: 10.2174/2213240601999131122114330