5-Nitroimidazoles are drugs having both antiprotozoal and antibacterial activity, but show mutagenicity and
development of resistance particularly with metronidazole. For the development of new potentially safer derivatives, we
investigated new strategies of synthesis: such as Vicarious Nucleophilic Substitution of hydrogen (VNS), palladiumcatalyzed
cross-coupling reactions (Suzuki-Miyaura, Sonogashira…) and electron transfer reactions (Unimolecular Radical
Nucleophilic Substitution (SRN1), TDAE methodology) applied in 5-nitroimidazole series.
Keywords: Anti-infectious agents, Electron transfer reactions, 5-Nitroimidazole, Palladium-catalyzed reactions, VNS reaction.
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