Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


The Study of the Biological Activity of Amino-Substituted Benzofuroxans

Author(s): Elena A. Chugunova, Alexandra D. Voloshina, Rezeda E. Mukhamatdinova, Igor V. Serkov, Alexey N. Proshin, Elmira M. Gibadullina, Alexander R. Burilov, Natalia V. Kulik, Vladimir V. Zobov, Dmitry B. Krivolapov, Alexey B. Dobrynin, Regis Goumont.

Graphical Abstract:


As a part of our ongoing studies in developing new derivatives as dual antibacterial/antifungal agents, we describe the synthesis of novel amino substituted benzofuroxan derivatives. These compounds were tested for their antifungal activity against various strains. It is shown that their antimicrobial and antifungal activities depend on the structure of the amino moiety, on the position and on the nature of the substituents of the benzofuroxan ring. They displayed good bacteriostatic and fungistatic activities comparable to those of reference drugs. The more active benzofuroxan derivatives have been studied intraperitoneally in mice to get a first estimation of their toxicity. Preliminary results have also shown that some derivatives are able to inhibit enzymes such as GDH (glucose dehydrogenase).

Keywords: Bacteriostatic activity, Fungistatic activity, Intraperitoneal introduction, Amine substitution, Benzofuroxan.

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Article Details

Year: 2014
Page: [502 - 512]
Pages: 11
DOI: 10.2174/1570180810666131122010403
Price: $58