Novel Urea/Thiourea Derivatives of Quinazolin-4(3H)-one: Design, Synthesis, Antimicrobial and Anti-TB Study
Dhruvin R. Shah, Rahul P. Modh, Dhara V. Desai and Kishor H. Chikhalia
Affiliation: Department of Chemistry, School of Sciences, Gujarat University, Ahmedabed-380009, Gujarat, India.
In an attempt to control multidrug resistant dilemma, a library of quinazolinone based on two novel series was
rationalized and synthesized with simple and efficient etiquette. A number of compounds encompass ethyl thioureidic
backbone, structurally related to PETT (Phenyl Ethyl Thiazolyl Thiourea) congeners. All the final synthesized compounds
were characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis. The newly synthesized compounds were
studied for efficacy against several bacteria (Staphylococcus Aureus, Bacillus Cereus, Escherichia Coli, Pseudomonas
Aeruginosa, Klebsiella Pneumoniae, Salmonella Typhi, Proteus Vulgaris, Shigella Flexneria) and fungi (Candida Albicans,
Aspergillus Niger, Aspergillus Clavatus) using the broth dilution technique. Moreover, these compounds were also
screened for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC
Keywords: Antimicrobial, Antimycobacterial, Minimum Inhibitory Concentration, Quinazolinone; Synthesis, Thiourea, Urea.
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