Anti-TB Evaluation of Natural Products From Plants
Pp. 158-179 (22)
Marcus V.N. de Souza
Natural products represent an outstanding source of compounds able to play
an important role in the treatment of several human diseases. For example, plants are an
incredible source of bioactive compounds isolated from different species with an
impressive structural diversity, representing a field of inspiration for the development of
new drugs. The importance of natural products in drug discovery can be noted in the
large number of drugs derived from plants available against different classes of disease.
Due to the importance of the plants in drug discovery, several compounds have been
isolated and evaluated from different species against Mycobacterium tuberculosis,
which some of the most promising it will be described in this chapter.
Tuberculosis, Mycobacterium tuberculosis, natural products, plants,
semi-synthesis, synthesis, analogues, treatment, multi-drug-resistant tuberculosis
(MDR TB), extensive-drug-resistant tuberculosis (XDR TB), target, mechanism
of action, biological evaluation, drug development.
Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil.