Tuberculosis Treatment: The Search For New Drugs

Tuberculosis Treatment: The Search For New Drugs

Despite the high impact on human health caused by Tuberculosis (TB) infections worldwide, nearly 45 years have passed since a novel drug was introduced for its treatment. As MDR-TB and XDR-TB cases ri
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Anti-TB Evaluation of Natural Products From Plants

Pp. 158-179 (22)

Marcus V.N. de Souza

Abstract

Natural products represent an outstanding source of compounds able to play an important role in the treatment of several human diseases. For example, plants are an incredible source of bioactive compounds isolated from different species with an impressive structural diversity, representing a field of inspiration for the development of new drugs. The importance of natural products in drug discovery can be noted in the large number of drugs derived from plants available against different classes of disease. Due to the importance of the plants in drug discovery, several compounds have been isolated and evaluated from different species against Mycobacterium tuberculosis, which some of the most promising it will be described in this chapter.

Keywords:

Tuberculosis, Mycobacterium tuberculosis, natural products, plants, semi-synthesis, synthesis, analogues, treatment, multi-drug-resistant tuberculosis (MDR TB), extensive-drug-resistant tuberculosis (XDR TB), target, mechanism of action, biological evaluation, drug development.

Affiliation:

Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil.