Tuberculosis Treatment: The Search For New Drugs

Tuberculosis Treatment: The Search For New Drugs

Despite the high impact on human health caused by Tuberculosis (TB) infections worldwide, nearly 45 years have passed since a novel drug was introduced for its treatment. As MDR-TB and XDR-TB cases ri
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Important Historical Facts of Tuberculosis Treatment and Drug Development

Pp. 3-37 (35)

Marcus V.N. de Souza


In this chapter will be highlight some important historical facts of tuberculosis treatment and drug development, such as theories, studies and treatment of TB between 17-20th Century, historical aspects of TB drug discovery, side effects, fixed-dose combinations, causes of the resurgence of TB, AIDS, multi-drug-resistant tuberculosis (MDR TB) and extensive-drug- resistant (XDR).


Tuberculosis, Mycobacterium tuberculosis, drugs, treatment, fixeddose combinations, multi-drug-resistant tuberculosis (MDR TB), extensive-drugresistant tuberculosis (XDR TB), natural products, synthesis, AIDS, theories, historical aspects.


Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil.