Tuberculosis Treatment: The Search For New Drugs

Tuberculosis Treatment: The Search For New Drugs

Despite the high impact on human health caused by Tuberculosis (TB) infections worldwide, nearly 45 years have passed since a novel drug was introduced for its treatment. As MDR-TB and XDR-TB cases ri
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Important Historical Facts of Tuberculosis Treatment and Drug Development

Pp. 3-37 (35)

Marcus V.N. de Souza

Abstract

In this chapter will be highlight some important historical facts of tuberculosis treatment and drug development, such as theories, studies and treatment of TB between 17-20th Century, historical aspects of TB drug discovery, side effects, fixed-dose combinations, causes of the resurgence of TB, AIDS, multi-drug-resistant tuberculosis (MDR TB) and extensive-drug- resistant (XDR).

Keywords:

Tuberculosis, Mycobacterium tuberculosis, drugs, treatment, fixeddose combinations, multi-drug-resistant tuberculosis (MDR TB), extensive-drugresistant tuberculosis (XDR TB), natural products, synthesis, AIDS, theories, historical aspects.

Affiliation:

Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil.