1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules
Samrat A. Khedkar and Pratibha B. Auti
Affiliation: Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Narhe, Pune-41. Maharashtra. India.
Keywords: Antihypertensive, biological and pharmacological action, calcium channel modulating agents, cardiovascular
disease, 1, 4-dihydropyridine, therapeutic application.
The 1, 4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological
actions. It represents one of the most important groups of calcium-channel modulating agents and has experienced
widespread use in the treatment of cardiovascular disease which includes antihypertensive, antianginal, vasodilator and
cardiac depressants activities. It also shows antibacterial, anticancer, antileishmanial, anticoagulant, anticonvulsant,
antitubercular, antioxidant, antiulcer, CFTR, antimalarials, neuroprotection properties, HIV-1 protease inhibitors,
antifertility activities and many more. There are many drugs available in market which contains 1, 4-dihydropyridines ring
as basic scaffold. Basic motive of this review is to disclose various therapeutic applications of 1, 4-dihydropyridine
derivatives reported by other researchers during their research work in 2001 to 2011.
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