Antibody-Targeted Immunoliposomes for Cancer Treatment

Author(s): Jie Gao, Huaiwen Chen, Hao Song, Xiao Su, Fangfang Niu, Wei Li, Bohua Li, Jianxin Dai, Hao Wang, Yajun Guo.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 14 , 2013

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Abstract:

Monoclonal antibodies (mAbs) or their derivatives are often used as the targeted ligands in the ligand targeted liposomes (LTLs). LTLs modified with mAbs or their derivatives are defined as immunoliposomes. Immunoliposomes can be designed to improve the pharmacological properties of conventional drugs. The development of immunoliposomes, which perfectly combines antibody engineering and liposomes, is becoming a possible state-of-the-art in liposome research. This review discusses the recent characterization and therapeutic effects of immunoliposomes in cancer therapy. The recent advances in the field of immunoliposomes for the treatment of cancer are summarized as follows: antibody engineering, current antibody conjugation strategies, characterization and therapeutic effects of immunoliposomes and the future perspective of immunoliposomes. Although antibody targeted immunoliposomes are being developed rapidly, there has been still a number of hot spots in research that require sustained effort for success. It is reasonable to predict that immunoliposomes will be approved for clinic use, and patients will benefit much from this cancer targeted therapy.

Keywords: Antibody engineering, Antibodies conjugation, Immunoliposomes, Gene therapy, Chemotherapy, Cancer.

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Article Details

VOLUME: 13
ISSUE: 14
Year: 2013
Page: [2026 - 2035]
Pages: 10
DOI: 10.2174/1389557513666131119202717
Price: $58

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