The Antiepileptic Potential of Nucleosides

Author(s): Z. Kovacs, K.A. Kekesi, G. Juhasz, A. Dobolyi.

Journal Name:Current Medicinal Chemistry

Volume 21 , Issue 6 , 2014

Abstract:

Despite newly developed antiepileptic drugs to suppress epileptic symptoms, approximately one third of patients remain drug refractory. Consequently, there is an urgent need to develop more effective therapeutic approaches to treat epilepsy. A great deal of evidence suggests that endogenous nucleosides, such as adenosine (Ado), guanosine (Guo), inosine (Ino) and uridine (Urd), participate in the regulation of pathomechanisms of epilepsy. Adenosine and its analogues, together with non-adenosine (non-Ado) nucleosides (e.g., Guo, Ino and Urd), have shown antiseizure activity. Adenosine kinase (ADK) inhibitors, Ado uptake inhibitors and Ado-releasing implants also have beneficial effects on epileptic seizures. These results suggest that nucleosides and their analogues, in addition to other modulators of the nucleoside system, could provide a new opportunity for the treatment of different types of epilepsies. Therefore, the aim of this review article is to summarize our present knowledge about the nucleoside system as a promising target in the treatment of epilepsy.

Keywords: Epilepsy treatment, nucleosides.

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Article Details

VOLUME: 21
ISSUE: 6
Year: 2014
Page: [788 - 821]
Pages: 34
DOI: 10.2174/1381612819666131119154505
Price: $58