Enrofloxacin: Pharmacokinetics and Metabolism in Domestic Animal Species

Author(s): Cristina López-Cadenas, Matilde Sierra-Vega, Juan J. García-Vieitez, M. José Diez-Liébana, Ana Sahagún-Prieto, Nélida Fernández- Martínez.

Journal Name: Current Drug Metabolism

Volume 14 , Issue 10 , 2013

Become EABM
Become Reviewer

Abstract:

Enrofloxacin is a fluorquinolone exclusively developed for use in veterinary medicine (1980). The kinetics of enrofloxacin are characterized, in general terms, by high bioavailability in most species and rapid absorption after IM, SC or oral administration. However, several studies reported that enrofloxacin showed low bioavailability after oral administration in ruminants. This drug has a broad distribution in the organism, excellent tissue penetration and long serum half-life. Also, enrofloxacin is characterized by a low host toxicity, a broad antibacterial spectrum and high bactericidal activity against major pathogenic bacteria (both Gram-positive and Gramnegative), and intracellular organisms found in diseased animals. The kinetics vary according to the route of administration, formulation, animal species, age, body condition, and physiological status, all of which contribute to differences in drug efficacy. The pharmacokinetic properties of drugs are closely related to their pharmacological efficiency, so it is important to know their behavior in each species that is used. This article reviews the pharmacokinetics of enrofloxacin in several domestic animal species.

Keywords: Absorption, animal species, distribution, enrofloxacin, excretion, metabolism, pharmacokinetics.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 14
ISSUE: 10
Year: 2013
Page: [1042 - 1058]
Pages: 17
DOI: 10.2174/1389200214666131118234935
Price: $58

Article Metrics

PDF: 39