MicroRNAs and Major Blood-borne Infectious Viral Diseases
Neetu Dahiya and Chintamani D. Atreya
Affiliation: 8800 Rockville pike, Building 29A, Room no. 2C11, Bethesda, MD 20892, USA.
The presence of microRNAs (miRNAs) and their ease of detection in body fluids including serum and whole
blood have opened new avenues for developing novel non-invasive methods for diagnostics and therapeutic applications
for both infectious and noninfectious diseases. Blood-borne infectious viral diseases pose challenge to public health at
large and, especially to health care workers, emergency responders and public safety personnel. Several studies have explored
these newly identified miRNAs in blood borne infectious diseases for various purposes. This review highlights and
focuses only on some of the available literature on the patient associated cellular miRNAs in blood-borne viral diseases
and its occasional extrapolation to infected cell cultures as it relates to blood-borne hepatitis C virus (HCV), hepatitis B
virus (HBV) and human immunodeficiency virus (HIV). Where appropriate, this review further points to the potential of
miRNAs as non-invasive early disease detection biomarkers for these viral infections as well as possible prospects and
challenges of miRNA-based therapies in treating these viral infections.
Keywords: Blood-borne, diseases, HBV, HCV, HIV-1, microRNA.
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