Synthesis, Characterization and Antitumor Activity of Novel Triazole/ Isoxazole Tagged Pyridine Hybrids

Author(s): Raju K, Chandra Shekhar A, Sathaiah G, Ravi Kumar A, Narsaiah B, Shanthan Rao P, Srujana R, Srigiridhar Kotamraju.

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 4 , 2014

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Abstract:

A series of novel 2-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methoxy) substituted pyridine, 1-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methyl)substituted pyridin-2(1H)-one was prepared from 2-oxo-6-phenyl/methyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 3 via propargylation followed by 1,3- dipolar cycloaddition of the propargyl derivatives 4 and 5. These triazole/isoxazole tagged pyridine derivatives were evaluated for antitumor activity against breast cancer cell lines such as MDA-MB-231, MCF-7 etc. The results indicated that compounds 6e, 6f, 8e and 8f were found to be active on MDA-MB-231, while 6h and 8h were active on MCF-7.

Keywords: Nicotinonitrile, propargylation, antitumor activity, 1, 2, 3-triazole, isoxazole.

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2014
Page: [293 - 302]
Pages: 10
DOI: 10.2174/1570178610666131118223356
Price: $58

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