N',N"'-[2,2'-[[1,1'-Biphenyl]-4,4'-diylbis(oxy)]bis(acetyl)]di(benzohydrazide) 3 was prepared by reaction of
2,2'-[1,1'-biphenyl]-4,4'-diylbis(oxy)]bisacetohydrazide 2 with benzoyl chloride. A new series of the arylidene 4-15 was
prepared by heating 2 with the following aldehydes: 4-flourobenzaldehyde, p-tolualdehyde, 2-hydroxy-3-
methoxybenzaldehyde, 2-chlorobenzaldehyde, isonicotinaldehyde (4-pyridine carboxaldehyde), benzaldehyde, 4-
chlorobenzaldehyde, picolinaldehyde (2-pyridine carboxaldehyde), 4-methoxybenzaldehyde (4-anisaldehyde), 3-
bromobenzaldehyde, 2,4,6-trimethoxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde (vaniline). The compounds
were evaluated against influenza virus. Two compounds showed moderate activity which means that with more
derivatization, better activity could be expected.