Novel Adjunctive Therapies for the Treatment of Tuberculosis

Author(s): A.A. Ordonez, M. Maiga, S. Gupta, E.A. Weinstein, W.R. Bishai, S.K. Jain.

Journal Name: Current Molecular Medicine

Volume 14 , Issue 3 , 2014

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Abstract:

Despite significant efforts to control tuberculosis (TB), the disease remains a major global threat, with an estimated 8.6 million new cases and 1.3 million deaths in 2012 alone. Significant treatment challenges include HIV co-infection, the dramatic rise of multidrug-resistant TB and the vast reservoir of latently infected individuals, who will develop active disease years after the initial infection. The long duration of chemotherapy also remains a major barrier to effective large scale treatment of TB. Significant advances are being made in the development of shorter and effective TB drug regimens and there is growing evidence that host-directed and “non-antimicrobial” pathogen-directed therapies, could serve as novel approaches to enhance TB treatments. This review highlights the rationale for using these therapies and summarizes some of the progress in this field.

Keywords: Corticosteroids, efflux pump inhibitors, microenvironment, inflammation, TNF-α.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2014
Page: [385 - 395]
Pages: 11
DOI: 10.2174/1566524013666131118112431
Price: $58

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