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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
Epub Full Text Article
DOI: 10.2174/1386207316666131117172549      Price:  $95

Liquid-phase Combinatorial Library Synthesis: Recent Advances and Future Perspectives

Author(s): Kuldipsinh P. Barot, Stoyanka Nikolova, Illiyan Ivanov and Manjunath D. Ghate
Liquid-phase combinatorial library synthesis is developed into the viable alternatives or adjunct across the broad spectrum of polymer-supported organic chemistry. It involves the use of soluble polymer supports in the combinatorial synthesis of peptides and small-molecular library compounds which acts as catalyst and reagent supports. It also involves high-throughput biological screening which generates and evaluates chemical leads for drug discovery development. In this review, liquid-phase combinatorial synthesis is shown as most efficient method of choice for the synthesis of most of the combinatorial library compounds with the specific approaches from different groups that states potentials of solution-phase synthesis
Development, general techniques, library formation, multi-step synthesis, recent advances
Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad-382481, Gujarat, India