Abstract
Bladder cancer stem cell research is rapidly expanding based on the knowledge of cancer stem cells from various cancer types and normal stem cells as models. In various cancer types, cancer stem cells have been implicated in therapeutic resistance and relapse after initial therapy. Understanding how cancer stem cells differ from bulk cancer cells and how cancer stem cells contribute to relapse and resistance are essential to develop novel therapeutics to target cancer stem cells effectively. Here we review the latest information on bladder cancer stem cells, their biological characteristics, including their response to treatment, recurrence, immune context and technical problems encountered in bladder cancer stem cell research.
Keywords: Blebbishields, cancer stem cells, CD44, c-Met, neutrophils, T-cells, VEGFR2.
Current Stem Cell Research & Therapy
Title:Bladder Cancer Stem Cells: Biological and Therapeutic Perspectives
Volume: 9 Issue: 2
Author(s): Goodwin Jinesh G., Daniel Levi Willis and Ashish M. Kamat
Affiliation:
Keywords: Blebbishields, cancer stem cells, CD44, c-Met, neutrophils, T-cells, VEGFR2.
Abstract: Bladder cancer stem cell research is rapidly expanding based on the knowledge of cancer stem cells from various cancer types and normal stem cells as models. In various cancer types, cancer stem cells have been implicated in therapeutic resistance and relapse after initial therapy. Understanding how cancer stem cells differ from bulk cancer cells and how cancer stem cells contribute to relapse and resistance are essential to develop novel therapeutics to target cancer stem cells effectively. Here we review the latest information on bladder cancer stem cells, their biological characteristics, including their response to treatment, recurrence, immune context and technical problems encountered in bladder cancer stem cell research.
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Cite this article as:
G. Jinesh Goodwin, Willis Levi Daniel and Kamat M. Ashish, Bladder Cancer Stem Cells: Biological and Therapeutic Perspectives, Current Stem Cell Research & Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574888X08666131113123051
DOI https://dx.doi.org/10.2174/1574888X08666131113123051 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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