Bupropion-SR for Smoking Reduction and Cessation in Alcohol-Dependent Outpatients: A Naturalistic, Open-Label Study
Maher Karam-Hage, Jason D. Robinson, Ashutosh Lodhi and Kirk J. Brower
Affiliation: Department of Behavioral Science, Unit 1330, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Houston, TX 77030, USA.
Background: We sought to determine whether sustained-release bupropion (bupropion-SR) reduces smoking
and promotes smoking cessation among alcohol-dependent (AD) smokers while they are in early recovery from alcohol.
Methods: We conducted an open-label, naturalistic study among AD smokers enrolled in an outpatient treatment program.
The treatment group (n=58) was offered bupropion-SR and brief smoking cessation counseling. A control group (n=57)
was matched to the treatment group by age, sex, ethnicity, cigarette use, and years of alcohol dependence. The controls
received no smoking cessation intervention. We collected tobacco and alcohol abstinence data for 6 months after
Results: Participants in the treatment group were more likely to abstain from smoking than controls, at any of the followup
time points. The treatment group smoked less cigarettes per day (CPD) at baseline, 30 days and 180 days post-baseline,
compared to controls. These findings persisted after adjusting for possible covariates.
Conclusion: Bupropion-SR may be helpful to quit or reduce smoking for recently abstinent AD individuals.
Keywords: Alcohol dependence, bupropion, nicotine, treatment, smoking, cessation.
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