Circulating Levels of Soluble Angiogenic Factors in Multiple Myeloma: Correlation with Parameters of Disease Activity and Prognosis
Michael G. Alexandrakis and George Tsirakis
Affiliation: Hematology Dept., University Hospital of Heraklion, Voutes, Heraklion, Crete, Greece, Zip code: 71110, P.O. Box1352.
Keywords: Angiogenesis, bone marrow, chemokines, cytokines, microvascular density, multiple myeloma, prognosis.
The progression of multiple myeloma depends on bone marrow microenvironment that can offer favorable
conditions for its growth. Among the most important features of the disease is the alteration of bone marrow microenvironment,
including dysregulation of various molecules with consequent increased angiogenic potential, extended bone
disease, resistance to any likely therapy and furthermore direct growth of myeloma clone. Angiogenesis, as can be estimated
by immunohistochemical staining of blood vessels, i.e. microvascular density, is a hallmark in the progress of many
malignancies, including multiple myeloma. Many pro-angiogenic molecules participate in the process, being aberrantly or
over-expressed by myeloma and other cells of bone marrow. Those molecules, possessing multiple properties, may circulate
in peripheral blood and therefore could be measured. Here we present an overview of the most important molecules
that participate, directly and indirectly, in the angiogenic process of multiple myeloma and try to evaluate their role, as
factors of disease activity and moreover of prognosis. Furthermore, many of circulating angiogenic molecules have been
constituted possible targets for therapeutic interventions. All this provided information contributes to a better comprehension
of the complex pathophysiology of multiple myeloma.
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