Immunology of Pregnancy 2013

Indexed in: Book Citation Index, Science Edition, EBSCO.

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a ...
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Part E: Interleukin-10: A Vascular and Anti-Inflammatory Cytokine Connecting the Pieces of the Pregnancy Puzzle

Pp. 313-334 (22)

Satyan Kalkunte, Tania Nevers, Eliana M.O. Lippe and Surendra Sharma

Abstract

Pregnancy is a unique and well-choreographed physiological phenomenon that involves dynamic maternal and fetal dialogue. Local immune tolerance, angiogenesis, cytokine and hormonal balance, cellular and molecular mimicry, genetic and epigenetic as well as environmental cues influence the pregnancy outcomes. Adverse pregnancy outcomes are a consequence of impairment of more than one of these factors that results in adaptation failure. In this chapter, we propose a two hit hypothesis for adverse pregnancy outcomes (Fig. 1) with particular focus on gene-environment interactions, as we understand them through the prism of interleukin (IL-10) and a decade of research with IL-10-/- mice.

Keywords:

Pregnancy, IL10 cytokine, infection, preterm birth, preeclampsia, angiogenesis, toxicants, Tregs.

Affiliation:

Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, Rhode Island 02912, USA.