Immunology of Pregnancy 2013

Indexed in: Book Citation Index, Science Edition, EBSCO.

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a ...
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Part C: A Summary of Cytokine Networks and Embryo: A Short Overview

Pp. 238-279 (42)

Gérard Chaouat

Abstract

In this relatively short review, after recaling the immunotrophism theory and the Th1 /Th2 paradigm, and the fact that a major discovery in the field was that “immunologic” molecules are produced by cells of the reproductive tract of non-immune lineage, we try to summarize the main cytokines involvement in pregnancy, though redundancy and chaos like functions makes it sometimes impossible to ascribe a defined role to a single cytokine or even cytokine family.

Keywords:

Cytokine, Interleukin, Angiogenesis, Complement, Th1, Th2, Tregs, NK, Network, Uterus, Placenta, Implantation, Pregnancy, Failure, Abortion.

Affiliation:

Director of Research Emeritus. U976 INSERM /UMR 976 CNRS Saint Louis Hospital 75010, Paris, France.