Immunology of Pregnancy 2013

Indexed in: EBSCO.

Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a ...
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Innate and Adaptive Immunity in the Human Female Reproductive Tract: Bridging the Menstrual Cycle with Pregnancy

Pp. 3-58 (56)

Charles R. Wira, Mickey V. Patel, Mimi Ghosh, Zheng Shen and Marta Rodríguez-García

Abstract

The vaginal innate immune system represents the first line of defense against foreign organisms and pathogenic microbes. Through its major components, a natural balance is maintained and disease is averted. Many recent advances have furthered our knowledge of this intricate equilibrium and the contribution of each element to the final homeostasis. Various adverse obstetric and gynecologic conditions have been traced to abnormalities in the vaginal environment. This review highlights the importance of this subject in future interventions and opens the venue for future research.

Keywords:

Immunity, humoral, cellular, adaptative, innate, vagin, uterus, hormones, lymphocytes, T Cells, B Cells, macrophages, dendritic cells, NK cell cytokines, chemokines, pathogens, protection, HIV.

Affiliation:

Department of Physiology and Neurobiology Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, NH 03756, USA.