Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different
approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase
reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase
reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase
reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in
combination with butyrylcholinesterase) and also as post-exposure treatment.
Keywords: Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote,
organophosphate, reactivator, protection, oxime, toxicity.
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