Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides

Author(s): Kamil Kuca, Daniel Jun, Kamil Musilek, Miroslav Pohanka, Jana Zdarova Karasova, Ondrej Soukup.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 14 , 2013

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Abstract:

Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.

Keywords: Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote, organophosphate, reactivator, protection, oxime, toxicity.

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Article Details

VOLUME: 13
ISSUE: 14
Year: 2013
Page: [2102 - 2115]
Pages: 14
DOI: 10.2174/13895575113136660108
Price: $58

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