Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery
Hema Chaudhary, Samita, Nitika Puri and Vikash Kumar
Affiliation: PDM College of Pharmacy, Bahadurgarh, Haryana, India.
Nanotechnology is an emergent field with numerous applications in drug delivery, clinical medicine,
nutriceuticals as well as in other fields also. In this techno, Solid lipid nanoparticles (SLN) is a part which consist solid
colloidal particles ranging in size from 1 to 1000 nm and act as “magic bullet” when coupled with ligands/targeting
ligands. SLN consisting of a solid-lipid promising advance delivery of lipophilic drugs and also used as an alternate for
conventional carriers such as micro-emulsions, liposomes and nanoparticles based on natural/synthetic polymers. They are
formulated from synthetic/natural lipids and optimize the drug delivery to provide a protection to sensitive drugs and
obtain better/improve bioavailability with less toxicity (as compared to polymeric NPs) due to its biodegradable/bioacceptable
nature. Moreover, Surface Modified SLNs is a new promising approach for protein loading and antigen
Keywords: Nanotechnology, solid lipid nanoparticles (SLN), drug delivery, toxicity.
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