Synthesis and In vitro Analysis of Novel Dihydroxyacetophenone Derivatives with Antimicrobial and Antitumor Activities
Ana Maria Zbancioc, Anca Miron, Cristina Tuchilus, Pincu Rotinberg, Cosmin Teodor Mihai, Ionel I. Mangalagiu and Gheorghita Zbancioc
Affiliation: “Al. I. Cuza” University of Iasi, Department of Organic and Biochemistry, 11 Carol I, Iasi-700506, Romania.
Herein we report a feasible study concerning the design, syntheses and in vitro antimicrobial and antitumoral
activities of some novel compounds with dihydroxyacetophenone (DA) moiety. An efficient and general method for the
preparation of diazine with dihydroxyacetophenone (DDA) skeleton under conventional thermal heating (TH), microwave
(MW) and ultrasounds (US) irradiation is presented. Antimicrobial and antitumoral tests prove that some dihydroxyacetophenone
compounds (the brominated derivatives BrDA 3) have a significant biological activity. It is also to be pointed out
that, basically all the dihydroxyacetophenone derivatives proved to have a powerful antibacterial activity against drug resistant
Gram-negative strain Pseudomonas aeruginosa ATCC 27853. Of particular interest could be the excellent antibacterial
activity of our dihydroxyacetophenone compounds against drug resistant Gram-negative strain Pseudomonas aeruginosa.
Keywords: Antimicrobial, antitumoral, dihydroxyacetophenone, microwaves, phthalazine, pyridazine, ultrasounds.
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