Peptide-based nanomaterials are widely used as nanocarriers for catalysis, drug delivery, and gene delivery. In
this paper, we designed and synthesized the amphiphilic tripeptides through solution phase synthesis. The tripeptides were
purified by column chromatography and the molecular structures were confirmed by 1H NMR and TOF-MS. The tripeptides
could self-assemble into spherical nanoparticles in aqueous media with a low critical aggregation concentration. The
size and morphology of the nanoparticles were performed by dynamic light scattering, scanning electron microscopy and
transmission electron microscope. The peptide-based nanoparticles were used as biocompatible nanocarriers for encapsulating
hydrophobic doxorubicin (DOX) to achieve controlled release. The CCK-8 assay indicated that the peptide-based
nanocarriers could enhance cellular uptake and drug efficacy of DOX to A549 tumor cell line. These results showed that
the self-assembly of amphiphilic tripeptides provided a facile strategy to fabricate nanoparticles for anti-tumor drug delivery.
Keywords: Amphiphilic tripeptide, controlled release, cytotoxicity, drug delivery, nanoparticles, self-assembly.
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