Renal Cell Carcinoma in a Patient with Rheumatoid Arthritis Treated with Adalimumab
Senol Kobak, Ahmet Karaarslan and Yunus Aktakka
Affiliation: Department of Rheumatology, Faculty of Medicine, Sifa University, 35100-Bornova/Izmir-Turkey.
Rheumatoid arthritis (RA) is a chronic erosive inflammatory disease which can involve the locomotor system
and cause systemic involvement. The efficacy and safety of anti-TNF-alpha drugs have been shown in active RA cases
that are resistant to traditional disease-modifying antirheumatic drugs. However, it is well known that anti-TNF-alpha
drugs may cause lymphomas and various solid malignancies. On the other hand, there are studies on the efficacy of anti-
TNF-alpha drugs in the treatment of resistant renal cell cancer. This case report presents a 57-year-old female patient with
hematuria who had been followed up with the diagnosis of RA for 20 years and had been using adalimumab for the last 4
years. A solid mass was found in the left kidney in the abdominal ultrasonography and computed tomography.
Nephrectomy was performed by general surgery. Histopathological findings of the specimen were consistent with renal
Keywords: Adalimumab, renal cell carcinoma, rheumatoid arthritis.
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