Renal Cell Carcinoma in a Patient with Rheumatoid Arthritis Treated with Adalimumab
Senol Kobak, Ahmet Karaarslan and Yunus Aktakka
Affiliation: Department of Rheumatology, Faculty of Medicine, Sifa University, 35100-Bornova/Izmir-Turkey.
Keywords: Adalimumab, renal cell carcinoma, rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic erosive inflammatory disease which can involve the locomotor system
and cause systemic involvement. The efficacy and safety of anti-TNF-alpha drugs have been shown in active RA cases
that are resistant to traditional disease-modifying antirheumatic drugs. However, it is well known that anti-TNF-alpha
drugs may cause lymphomas and various solid malignancies. On the other hand, there are studies on the efficacy of anti-
TNF-alpha drugs in the treatment of resistant renal cell cancer. This case report presents a 57-year-old female patient with
hematuria who had been followed up with the diagnosis of RA for 20 years and had been using adalimumab for the last 4
years. A solid mass was found in the left kidney in the abdominal ultrasonography and computed tomography.
Nephrectomy was performed by general surgery. Histopathological findings of the specimen were consistent with renal
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