An Overview of Partial Synthesis and Transformations of Secosteroids
Katarina Penov Gasi, Marija Sakac, Suzana Jovanovic-Santa and Evgenija Djurendic
Pages 216-259 (44)
Secosteroids are an important group of modified steroids, which exhibits a variety of different biological activities. Studies on
secosteroids have shown that modifications of the rigid tetracyclic steroidal carbon skeleton by cleavage of the internal C-C bonds
provides more flexible compounds with new biological properties. The search for steroid compounds analogs with improved biological
properties includes ring transformation into seco system. The recent development in the partial syntheses of secosteroids is described
herein, as well as studies of methods for modifications of such molecules.
Secosteroids, partial synthesis, reactivity, modification.
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21 000 Novi Sad, Serbia.