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Current Organic Chemistry
ISSN (Print): 1385-2728
ISSN (Online): 1875-5348
VOLUME: 18
ISSUE: 2
DOI: 10.2174/13852728113176660147      Price:  $58









An Overview of Partial Synthesis and Transformations of Secosteroids

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Author(s): Katarina Penov Gasi, Marija Sakac, Suzana Jovanovic-Santa and Evgenija Djurendic
Pages 216-259 (44)
Abstract:
Secosteroids are an important group of modified steroids, which exhibits a variety of different biological activities. Studies on secosteroids have shown that modifications of the rigid tetracyclic steroidal carbon skeleton by cleavage of the internal C-C bonds provides more flexible compounds with new biological properties. The search for steroid compounds analogs with improved biological properties includes ring transformation into seco system. The recent development in the partial syntheses of secosteroids is described herein, as well as studies of methods for modifications of such molecules.
Keywords:
Secosteroids, partial synthesis, reactivity, modification.
Affiliation:
Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21 000 Novi Sad, Serbia.