Bone and soft-tissue sarcomas tend to present in young adults. A wide variety of serological markers have been
associated with osteosarcoma. Tumor markers involved in angiogenesis, cell adhesion, apoptosis, and the cell cycle have
been shown to play an important role in osteosarcoma growth, differentiation, and metastasis. However, there are no
universal and specific serum tumor markers for early diagnosis of osteosarcoma and primary screening in risk groups. There
is strong empirical evidence that the IGF signal transduction pathway may be important in osteosarcoma. Several patents
of IGF and molecular biomarkers/panels in osteosarcoma have been reported. The tissue/serum biomarker panels using
high-throughput technology molecular signatures will have a role in early detection of the disease and noninvasive testing.
Keywords: Biomarkers, IGF-1, osteosarcoma, patents, tumor markers.
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