Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK

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Diet and Metabolic Syndrome: An Overview

Author(s): Deirdre Keane, Stacey Kelly, Niamh P. Healy, Maeve A. McArdle, Kieran Holohan and Helen M. Roche

Affiliation: Nutrigenomics Research Group, Food for Health Ireland, UCD Conway Institute & UCD Institute of Food and Health, University College Dublin, Dublin 4, Ireland.

Keywords: Diets, fatty acids, functional foods, glycaemic index, metabolic syndrome, nutrition.

Abstract:

The metabolic syndrome (MetS) is a complex multifactorial disorder and its incidence is on the increase worldwide. Due to the definitive link between obesity and the MetS weight loss strategies are of prime importance in halting the spread of MetS. Numerous epidemiological studies provide evidence linking dietary patterns to incidence of MetS symptoms. As a consequence of the epidemiology studies, dietary intervention studies which analyse the effects of supplementing diets with particular nutrients of interest on the symptoms of the MetS have been conducted. Evidence has shown that lifestyle intervention comprising changes in dietary intake and physical activity leads to an improved metabolic profile both in the presence or absence of weight loss thus highlighting the importance of a multi-faceted approach in combating MetS. Nutritional therapy research is not focused solely on reducing energy intake and manipulating macronutrient intake but is investigating the role of functional foods or bioactive components of food. Such bioactives which target weight maintenance and /or insulin sensitivity may have a potentially positive effect on the symptoms of the MetS. However the efficacy of different functional nutrients needs to be further defined and clearly demonstrated.

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Article Details

VOLUME: 11
ISSUE: 6
Page: [842 - 857]
Pages: 16
DOI: 10.2174/15701611113116660173