Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Regulation of EMT by Notch Signaling Pathway in Tumor Progression

Author(s): Yumei Li, Jia Ma, Xiujuan Qian, Qiong Wu, Jun Xia, Lucio Miele, Fazlul H. Sarkar, Zhiwei Wang.

Abstract:

Notch signaling pathway has been reported to play critical roles in the development and progression of human cancers because Notch signaling pathway is critically involved in many cellular processes including cell proliferation, survival, apoptosis, migration, invasion, angiogenesis, and metastasis. Emerging evidence suggests that Notch regulates EMT (Epithelial-to-Mesenchymal Transition), leading to tumor invasion and metastasis. Thus, this mini-review is focused on discussing the novel role of Notch signaling pathway in the regulation of EMT. Moreover, we summarized that Notch signaling pathway could be down-regulated by its inhibitors or natural compounds, resulting in the reversal of EMT to MET (Mesenchymal-to-Epithelial Transition), which could be a promising strategy for achieving better treatment outcome in patients diagnosed with cancer.

Keywords: Cancer, miRNA, natural compound, notch, oncogene, tumor suppressor gene.

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Article Details

VOLUME: 13
ISSUE: 9
Year: 2013
Page: [957 - 962]
Pages: 6
DOI: 10.2174/15680096113136660101
Price: $58