Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance

Author(s): Yulong Shang, Xiqiang Cai, Daiming Fan.

Abstract:

Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer. Poor responses to drug treatment can result in metastasis, cancer dissemination and death. Recently, the epithelial-mesenchymal transition (EMT) has been found to play a critical role in cancer drug resistance, but the nature of this intrinsic link remains unclear. This review summarizes recent advances in the understanding of drug resistance and focuses especially on the association between EMT and drug resistance. We discuss the roles of EMT in regulating drug resistance across different types of cancer, focusing simultaneously on the molecular mechanisms and potential pathways involved in the regulation of drug resistance by EMT. In addition, we discuss potential therapeutic strategies to target EMT to reverse drug resistance.

Keywords: BCL-2, Cancer stem cell, drug resistance, EMT, microRNA, NF-B, P-glycoprotein.

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Article Details

VOLUME: 13
ISSUE: 9
Year: 2013
Page: [915 - 929]
Pages: 15
DOI: 10.2174/15680096113136660097
Price: $58