Recent Patents on Biomarkers


Role of Cytokines and Matrix Metallo-Proteinases in Patients with Temporo- Mandibular Joint Internal Derangements and/or Osteoarthritis

Author(s): Andrea Testa, Rosalia Leonardi, Mugurel C. Rusu, Jessica Valentino, Salvatore Giunta, Giuseppe Musumeci, Carla Loreto.


The purpose of this systematic review is to investigate on the relationship between synovial level of cytokines and matrix metallo-proteinases and temporo-mandibular joint (TMJ) internal derangements (IDs) and/or osteoarthritis (OA). Twelve studies were included in the review and markers were evaluated in respect to IDs and OA. Findings from these investigations highlighted that higher levels of IL1β, IL-6, IL-11, TGFβ1 were associated to TMJ’s OA; on the other hand, higher levels of MMP-2 and MMP-9 could correlate to ID without reduction (IDw/oR). Furthermore, higher levels of MMP-9 could associate also to severe condition of TMJ’s OA. The findings of this systematic review could represent a useful tool for diagnosis and prognosis of TMJ’s diseases, particularly about the effectiveness of arthroscopy and/or arthrocentesis in patients submitted to repeated surgical treatments. The paper also outlines some recent patents.

Keywords: Cytokines, matrix metallo-proteinases, osteoarthritis, temporo-mandibular disorders.

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Article Details

Year: 2013
Page: [157 - 163]
Pages: 7
DOI: 10.2174/22103090113036660011
Price: $100