Recent Patents on Biomarkers


Role of Cytokines and Matrix Metallo-Proteinases in Patients with Temporo- Mandibular Joint Internal Derangements and/or Osteoarthritis

Author(s): Andrea Testa, Rosalia Leonardi, Mugurel C. Rusu, Jessica Valentino, Salvatore Giunta, Giuseppe Musumeci and Carla Loreto

Affiliation: Department of Bio-Medical Sciences, Section of Anatomy, University of Catania, Italy.


The purpose of this systematic review is to investigate on the relationship between synovial level of cytokines and matrix metallo-proteinases and temporo-mandibular joint (TMJ) internal derangements (IDs) and/or osteoarthritis (OA). Twelve studies were included in the review and markers were evaluated in respect to IDs and OA. Findings from these investigations highlighted that higher levels of IL1β, IL-6, IL-11, TGFβ1 were associated to TMJ’s OA; on the other hand, higher levels of MMP-2 and MMP-9 could correlate to ID without reduction (IDw/oR). Furthermore, higher levels of MMP-9 could associate also to severe condition of TMJ’s OA. The findings of this systematic review could represent a useful tool for diagnosis and prognosis of TMJ’s diseases, particularly about the effectiveness of arthroscopy and/or arthrocentesis in patients submitted to repeated surgical treatments. The paper also outlines some recent patents.

Keywords: Cytokines, matrix metallo-proteinases, osteoarthritis, temporo-mandibular disorders.

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Article Details

Page: [157 - 163]
Pages: 7
DOI: 10.2174/22103090113036660011