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CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)
ISSN (Print): 1871-5273
ISSN (Online): 1996-3181
Epub Full Text Article
DOI: 10.2174/18715273113126660200      Price:  $95









Mitochondrial Neuroprotection in Traumatic Brain Injury: Rationale and Therapeutic Strategies

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Author(s): S Yokobori, Mazzeo AT, S Gajavelli and Bullock MR
Abstract:
Traumatic brain injury (TBI) is still the worldwide, leading cause of mortality and morbidity in young adults. The prognosis of TBI patients is strongly affected by secondary brain damage including mitochondrial dysfunctions. In many basic and clinical studies, mitochondrial dysfunctions, including the opening of mitochondrial permeability transition (mPT) pore, and treatments including cyclosporine A (CsA) have been studied. These evidences suggest an important role for mitochondria as therapeutic targets for neuroprotection after TBI.

This review summarizes the data about normal and pathological mitochondrial function after TBI, TBI pathobiology relating to mitochondrial dysfunction and therapeutic strategies including drug treatment. This review also mentioned about glucose, lactate, and pyruvate metabolisms in TBI, including the "astrocyte-neuron lactate shuttle (ANLS)" hypothesis. Mitochondrial pathophysiology in TBI has still been unclear.

Thus, the pharmacological treatment in TBI patient is still challenging. Now we hope this presenting review could help further understanding of this topic. Hopefully, this could help further development and innovation for drug therapies in TBI

Keywords:
Astrocyte-neuron lactate shuttle, apoptosis, cyclosporine A, mitochondrial dysfunction, mitochondrial permeability transition pore, secondary brain injury, traumatic brain injury
Affiliation:
Department of Neurosurgery, University of Miami Miller School of Medicine, Lois Pope LIFE Center, Room 3-20, 1095 NW 14th Terrace, Miami, FL 33136, USA