Combinatorial Chemistry & High Throughput Screening

Rathnam Chaguturu 
iDDPartners, 3 Edith Court
Princeton Junction
NJ 08550
USA

Back

Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction

Author(s): Abbas Rahmati, Zahra Khalesi and Tahmineh Kenarkoohi

Affiliation: Department of Chemistry, University of Isfahan, P.O. Box 81746-73441, Isfahan, Iran.

Keywords: Isatin, kojic acid, malononitrile, multi-component reaction, pyrano[3, 2-b]pyranone, pyranopyranone.

Abstract:

A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'- amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under reflux conditions, is described.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 17
ISSUE: 2
Page: [132 - 140]
Pages: 9
DOI: 10.2174/13862073113166660067