Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction
Abbas Rahmati, Zahra Khalesi and Tahmineh Kenarkoohi
Affiliation: Department of Chemistry, University of Isfahan, P.O. Box 81746-73441, Isfahan, Iran.
Keywords: Isatin, kojic acid, malononitrile, multi-component reaction, pyrano[3, 2-b]pyranone, pyranopyranone.
A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as
ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'-
amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under
reflux conditions, is described.
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