Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction

Author(s): Abbas Rahmati, Zahra Khalesi, Tahmineh Kenarkoohi.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 17 , Issue 2 , 2014

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Abstract:

A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'- amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under reflux conditions, is described.

Keywords: Isatin, kojic acid, malononitrile, multi-component reaction, pyrano[3, 2-b]pyranone, pyranopyranone.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2014
Page: [132 - 140]
Pages: 9
DOI: 10.2174/13862073113166660067
Price: $58

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