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Current Medicinal Chemistry
ISSN (Print): 0929-8673
ISSN (Online): 1875-533X
VOLUME: 21
ISSUE: 7
DOI: 10.2174/09298673113206660302      Price:  $58









Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents

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Author(s): M. Ashfaq, S.S.A. Shah, T. Najam, M.M. Ahmad, R. Tabassum and G. Rivera
Pages 911-931 (21)
Abstract:
Synthetic heterocyclic compounds have remarkable potential activity against diseases; thioamides, benzimidazoles, quinolones and derivatives with carboxylic acid and esters moieties have shown excellent activity against Mycobacterium tuberculosis. We reviewed antituberculosis activities of above compounds with reference to half maximal inhibitory concentration, minimum inhibitory concentration and structural-activity relationship which clearly indicate that electron- withdrawing groups are the main inducers of antimycobacterium activity. Comparison between clinically used drugs and new synthetic derivatives showed recent advances made in the last decade.
Keywords:
Antituberculosis, benzimidazoles, carboxylic acid, design, quinolones, thioamides.
Affiliation:
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.