Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents

Author(s): M. Ashfaq, S.S.A. Shah, T. Najam, M.M. Ahmad, R. Tabassum, G. Rivera.

Journal Name: Current Medicinal Chemistry

Volume 21 , Issue 7 , 2014

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Abstract:

Synthetic heterocyclic compounds have remarkable potential activity against diseases; thioamides, benzimidazoles, quinolones and derivatives with carboxylic acid and esters moieties have shown excellent activity against Mycobacterium tuberculosis. We reviewed antituberculosis activities of above compounds with reference to half maximal inhibitory concentration, minimum inhibitory concentration and structural-activity relationship which clearly indicate that electron- withdrawing groups are the main inducers of antimycobacterium activity. Comparison between clinically used drugs and new synthetic derivatives showed recent advances made in the last decade.

Keywords: Antituberculosis, benzimidazoles, carboxylic acid, design, quinolones, thioamides.

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Article Details

VOLUME: 21
ISSUE: 7
Year: 2014
Page: [911 - 931]
Pages: 21
DOI: 10.2174/09298673113206660302
Price: $58

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