Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents

Title:Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents

Volume: 21 Issue: 7

Author(s): M. Ashfaq, S.S.A. Shah, T. Najam, M.M. Ahmad, R. Tabassum and G. Rivera

Affiliation:

Keywords: Antituberculosis, benzimidazoles, carboxylic acid, design, quinolones, thioamides.

Abstract: Synthetic heterocyclic compounds have remarkable potential activity against diseases; thioamides, benzimidazoles, quinolones and derivatives with carboxylic acid and esters moieties have shown excellent activity against Mycobacterium tuberculosis. We reviewed antituberculosis activities of above compounds with reference to half maximal inhibitory concentration, minimum inhibitory concentration and structural-activity relationship which clearly indicate that electron- withdrawing groups are the main inducers of antimycobacterium activity. Comparison between clinically used drugs and new synthetic derivatives showed recent advances made in the last decade.

Cite this article as:

Ashfaq M., Shah S.S.A., Najam T., Ahmad M.M., Tabassum R. and Rivera G., Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents, Current Medicinal Chemistry 2014; 21 (7) . https://dx.doi.org/10.2174/09298673113206660302