Background:This study measured serum concentrations of vascular risk factors, asymmetric dimethylarginine
(ADMA) and symmetric dimethylarginine (SDMA) in a representative sample of older community-dwelling adults and
determined their associations with objective and subjective memory impairment. Methods: Data on clinical, lifestyle, and
demographic characteristics, serum ADMA, SDMA, and L-arginine (measured using LC-MS/MS) were collected from a
population-based sample of older Australian adults from the Hunter Community Study. Objective memory was measured
with the Audio Recorded Cognitive Screen (ARCS) neuropsychological battery and subjective memory impairment was
measured using the Memory Complaint Questionnaire (MAC-Q). Results: Multivariate analysis revealed that SDMA and
diabetes were significantly associated with objective memory impairment (Adjusted Odd ratio (AOR) = 3.90; 95% CI.
1.21 – 12.52 for fourth quartile (Q4) of SDMA. ADMA, SDMA, education, number of general practitioner visits and
atrial fibrillation were all significantly associated with subjective memory impairment. (AOR = 1.82; 95% CI. 1.04 – 3.18
for Q4 ADMA. Conclusions: Higher serum SDMA was associated with objective and subjective memory impairment
while higher serum ADMA was associated with subjective memory impairment.
Keywords: ADMA, Alzheimer’s disease, memory impairment, methylarginines, nitric oxide, older adults, SDMA.
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