The Epithelial-Stromal Interaction as a Potential Target for Breast Cancer Treatment
Bianca Maria Veneziani, Micaela Montanari, Maria Letizia Cataldo, Luigi Coppola, Agostina Nardone, Sara Corvigno, Carmine De Angelis, Grazia Arpino, Mario Giuliano, Chiara Carlomagno, Roberto Bianco and Sabino De Placido
Affiliation: Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery, University of Naples “Federico II “, Via S. Pansini 5, 80131 Naples, Italy.
Keywords: Epithelial stromal mesenchymal interaction, breast cancer, target therapy.
Tumor behavior and outcome are believed to be modified by undifferentiated stromal fibroblasts that surround
epithelial cells. An understanding of the biology of these fibroblasts could shed light on the mechanisms underlying tumor
growth, invasion and progression, and may suggest new targets for therapy. In breast cancer, interactions between malignant
breast epithelial cells and fibroblasts are responsible for estrogen biosynthesis. Preclinical studies showed that breast
cancer epithelial cells secrete factors that enhance the expression and activity of the estrogen-synthesizing enzyme aromatase
in undifferentiated adipose fibroblasts. Clinicopathological data showing an abundance of stroma cells in
breast cancer, and the clinical finding that aromatase inhibitors are effective in breast cancer treatment indicate that
stromal cells play a prominent role in the microenvironment of breast cancer tissue. The analysis of the stromal signature
could provide information about the molecules involved in the epithelial-stromal interaction and reveal new potential
treatment targets in distinct biological processes. This article focuses on breast cancer in terms of: 1) epithelial and stromal
cell populations; 2) epithelial-stromal signaling and targeted therapies; and 3) stroma-related molecular signatures as
a tool to identify potential candidate molecules for target therapy.
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