Regulatory Triangle of Neurodegeneration, Adult Neurogenesis and MicroRNAs
Tanisha Singh, Abhishek Jauhari, Ankita Pandey, Parul Singh, Aditya B Pant, Devendra Parmar and Sanjay Yadav
Affiliation: Developmental Toxicology Division, CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow-226001, India.
MicroRNAs (miRNAs) have emerged as a new class of RNA molecules which are short in length, less in
number but play bigger role in regulation of cellular events. miRNAs keep cellular homeostasis in tight control by fine
tuning expression of protein coding genes at post-transcriptional level. Neurogenesis and neurodegeneration are two
complex processes which are regulated by dynamic expression of regulatory proteins like transcription factors and
signaling proteins. Evidences are accumulating that expression of miRNAs play major role in fate determination of
neuronal cells undergoing neurogenesis or neurodegeneration. Neurodegeneration either induced by genetic factors or
environmental chemicals results in development of neurodegenerative disorders like Parkinson’s or Alzheimer’s. With
increasing acceptance of adult neurogenesis, it seems possible that inducing neurogenesis in adult brain can help in
fighting with neurodegenerative disorders. Regulatory RNA molecules, like miRNAs are presenting them as potential
therapeutic targets for inducing neurogenesis and controlling neurodegeneration. In the current review, we are exploring
the link between neurodegeneration and adult neurogenesis regulation by focusing on miRNAs.
Keywords: Adult neurogenesis, Alzheimer’s disease, central nervous system, MicroRNA, neurodegeneration, Parkinson
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