Oral squamous cell carcinoma (OSCC) is the most frequent malignancy of the oral cavity, highly invasive with
unfavourable prognosis and unimproved 5-year survival rate for at least two decades. Comprehensive analysis of the
proteome in OSCC patients (tissue tumor, blood and saliva) was extensively performed in the last years in order to
identify reliable biomarkers for early detection, prognosis or treatment efficacy. We discuss herein the up-dated recent
data regarding neoplastic / stromal interactions related biomarkers such as cadherins, catenins, matrix metalloproteinases,
snai1, snai2, desmoglein 3, ezrin, zyxin, ILK, EMMPRIN, bone sialoprotein, dentin sialophosphoprotein, osteopontin,
fascin, podoplanin, calreticulin. These molecules are involved either in cell-cell adhesion, cell-extracellular matrix interactions
or regulation of matrix metalloproteinases that are expressed in OSCC, most of them in correlation with tumor
aggressivity. The pattern of the expression of most of these biomolecules in correlation with prognosis and/or histopathologic
parameters with previously proven prognostic significance (such as tumor stage or presence of lymph node
metastases) recommend them as possible biomarkers; however, considering the multitude of the studies involving several
of this markers and the inhomogeneous results, further investigations are required in order to validate them for daily
Biomarker, epithelial to mesenchymal transition, extracellular matrix, neoplastic / stromal interactions, oral dysplasia,
oral squamous cell carcinoma.
Colentina University Hospital, Department of Pathology, 21 Stefan cel Mare, sector 2, 020125, Bucharest, Romania.