Abstract
We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.
Keywords: Antifungal activity, Aspergillus spp., Candida spp., cytotoxicity, Microporum canis, 1H-1, 2, 3-Triazoles, Tricophyton rubrum.
Medicinal Chemistry
Title:Synthesis of 1H-1,2,3-triazoles and Study of their Antifungal and Cytotoxicity Activities
Volume: 9 Issue: 8
Author(s): Iara F. da Silva, Prisicila R.C. Martins, Emanuelly G. da Silva, Sabrina B. Ferreira, Vitor F. Ferreira, Karen Regina C. da Costa, Marne C. de Vasconcellos, Emerson S. Lima and Fernando de C. da Silva
Affiliation:
Keywords: Antifungal activity, Aspergillus spp., Candida spp., cytotoxicity, Microporum canis, 1H-1, 2, 3-Triazoles, Tricophyton rubrum.
Abstract: We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.
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da Silva F. Iara, Martins R.C. Prisicila, da Silva G. Emanuelly, Ferreira B. Sabrina, Ferreira F. Vitor, C. da Costa Regina Karen, de Vasconcellos C. Marne, Lima S. Emerson and C. da Silva de Fernando, Synthesis of 1H-1,2,3-triazoles and Study of their Antifungal and Cytotoxicity Activities, Medicinal Chemistry 2013; 9 (8) . https://dx.doi.org/10.2174/1573406411309080010
DOI https://dx.doi.org/10.2174/1573406411309080010 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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