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Current Drug Targets
ISSN (Print): 1389-4501
ISSN (Online): 1873-5592
VOLUME: 15
ISSUE: 3
DOI: 10.2174/13894501113146660232      Price:  $58









Microneedle-Based Drug Delivery Systems for Transdermal Route

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Author(s): Maria Bernadete Riemma Pierre and Fabia Cristina Rossetti
Pages 281-291 (11)
Abstract:
Transdermal delivery offers an attractive, noninvasive administration route but it is limited by the skin’s barrier to penetration. Minimally invasive techniques, such as the use of microneedles (MNs), bypass the stratum corneum (SC) barrier to permit the drug’s direct access to the viable epidermis. These novel micro devices have been developed to puncture the skin for the transdermal delivery of hydrophilic drugs and macromolecules, including peptides, DNA and other molecules, that would otherwise have difficulty passing the outermost layer of the skin, the SC. Using the tools of the microelectronics industry, MNs have been fabricated with a range of sizes, shapes and materials. MNs have been shown to be robust enough to penetrate the skin and dramatically increase the skin permeability of several drugs. Moreover, MNs have reduced needle insertion pain and tissue trauma and provided controlled delivery across the skin. This review focuses on the current state of the art in the transdermal delivery of drugs using various types of MNs and developments in the field of microscale devices, as well as examples of their uses and clinical safety.
Keywords:
Drug delivery, microneedles, safety, skin penetration enhancement, stratum corneum, transdermal delivery.
Affiliation:
Faculdade de Farmacia, Laboratorio de Pesquisa e Desenvolvimento Farmacotecnico, Departamento de Medicamentos, Universidade Federal do Rio de Janeiro, Brasil, Av. Carlos Chagas Filho, 373, 21.941.590, Rio de Janeiro, Brazil.